Article
The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 2006
Lou Meizhen, Garrett Thomas P J, McKern Neil M, Hoyne Peter A, Epa V Chandana, Bentley John D, Lovrecz George O, Cosgrove Leah J, Frenkel Maurice J, Ward Colin W
Abstract excerpt
The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1-CR-L2) of human IR at 2.3 A resolution and compare it with the previously determined structure of the corresponding fragment of IGF1R. The most important differences seen...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cricetinae
- Crystallography, X-Ray
- Humans
- Insulin-Like Growth Factor I
- Ligands
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Binding