Article
Cognitive phenotypes of sequential staging in amyotrophic lateral sclerosis.
Cortex; a journal devoted to the study of the nervous system and behavior - 1 Apr 2018
Lulé Dorothée, Böhm Sarah, Müller Hans-Peter, Aho-Özhan Helena, Keller Jürgen, Gorges Martin, Loose Markus, Weishaupt Jochen H, Uttner Ingo, Pinkhardt Elmar, Kassubek Jan, Del Tredici Kelly, Braak Heiko, Abrahams Sharon, Ludolph Albert C
Abstract excerpt
Sequential spread of TDP-43 load in the brain may be a pathological characteristic of amyotrophic lateral sclerosis (ALS). Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) based marker of this pathological feature. Cognitive deficits known to be present in a subset of ALS patients might act as an additional in vivo clinical marker of disease spread. N = 139 patients with ALS were tested with...
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