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Article

Neuropsychological Sub-Phenotypes in Amyotrophic Lateral Sclerosis.

European journal of neurology - 1 Aug 2026

Poletti Barbara, Aiello Edoardo Nicolò, Consonni Monica, Iazzolino Barbara, Torre Silvia, Faltracco Veronica, Telesca Alessandra, Palumbo Francesca, Curti Beatrice, De Luca Giulia, Moreschi Arianna, Frisco Francesca, Bella Eleonora Dalla, Bersano Enrica, Riva Nilo, Verde Federico, Messina Stefano, Doretti Alberto, Maranzano Alessio, Morelli Claudia, Cappa Stefano Francesco, Calvo Andrea, Strong Michael J, Silani Vincenzo, Lauria Giuseppe, Chiò Adriano, Ticozzi Nicola

Abstract excerpt

BACKGROUND: This study aimed at identifying neuropsychological sub-phenotypes in amyotrophic lateral sclerosis (ALS) within the mild cognitive impairment (MCI) and mild behavioral impairment (MBI) frameworks. METHODS: We used individual task-/item-level data from the cognitive and behavioral sections of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) from 901 non-demented ALS to derive neuropsychological...

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Identifiers

PMID: 42545188
DOI: 10.1111/ene.70706
PMCID: PMC13431129

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