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Article

Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Dec 2010

Oliveira Tiago Gil, Chan Robin B, Tian Huasong, Laredo Mikael, Shui Guanghou, Staniszewski Agnieszka, Zhang Hong, Wang Lili, Kim Tae-Wan, Duff Karen E, Wenk Markus R, Arancio Ottavio, Di Paolo Gilbert

Abstract excerpt

Growing evidence implicates aberrant lipid signaling in Alzheimer's disease (AD). While phospholipases A2 and C have been recently shown to mediate key actions of amyloid β-peptide (Aβ) through a dysregulation of arachidonic acid and phosphatidylinositol-4,5-bisphosphate metabolism, respectively, the role of phospholipase D (PLD) has so far remained elusive. PLD produces phosphatidic acid (PA), a bioactive lipid...

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Source

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Identifiers

PMID: 21147981
DOI: 10.1523/JNEUROSCI.3317-10.2010
PMCID: PMC3004537

Genes

PLD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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