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Article

Role of phospholipase D in the lifespan of Caenorhabditis elegans.

Experimental & molecular medicine - 6 Apr 2018

Park Jeong-Hwan, Park Jeong-Woo, Lee Ju-Hyeon, Kim Dong-Yun, Hahm Jeong-Hoon, Bae Young-Seuk

Abstract excerpt

We have previously shown that phospholipase D (PLD) downregulation accelerates cellular senescence, which is widely believed to play an important role in aging, by stimulating reactive oxygen species (ROS) accumulation in human cells. In this study, we examined the role of PLD in aging using the nematode Caenorhabditis elegans. The mRNA level of pld-1 was found to be inversely correlated with aging. RNAi-mediated...

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Source

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Identifiers

PMID: 29622768
DOI: 10.1038/s12276-017-0015-8
PMCID: PMC5938010

Genes

PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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