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Article

Phosphorylated glycosphingolipids essential for cholesterol mobilization in Caenorhabditis elegans.

Nature chemical biology - 1 Jun 2017

Boland Sebastian, Schmidt Ulrike, Zagoriy Vyacheslav, Sampaio Julio L, Fritsche Raphael F, Czerwonka Regina, Lübken Tilo, Reimann Jakob, Penkov Sider, Knölker Hans-Joachim, Kurzchalia Teymuras V

Abstract excerpt

The nematode Caenorhabditis elegans requires exogenous cholesterol to survive and its depletion leads to early developmental arrest. Thus, tight regulation of cholesterol storage and distribution within the organism is indispensable. Here, we present a novel class of C. elegans phosphorylated glycosphingolipids, phosphoethanolamine glucosylceramides (PEGCs), capable of rescuing larval arrest induced by sterol...

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Identifiers

PMID: 28369040
DOI: 10.1038/nchembio.2347

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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