Article
Deep sequencing of HBV pre-S region reveals high heterogeneity of HBV genotypes and associations of word pattern frequencies with HCC.
PLoS genetics - 1 Feb 2018
Bai Xin, Jia Jian-An, Fang Meng, Chen Shipeng, Liang Xiaotao, Zhu Shanfeng, Zhang Shuqin, Feng Jianfeng, Sun Fengzhu, Gao Chunfang
Abstract excerpt
Hepatitis B virus (HBV) infection is a common problem in the world, especially in China. More than 60-80% of hepatocellular carcinoma (HCC) cases can be attributed to HBV infection in high HBV prevalent regions. Although traditional Sanger sequencing has been extensively used to investigate HBV sequences, NGS is becoming more commonly used. Further, it is unknown whether word pattern frequencies of HBV reads by...
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