Article
Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
Journal of virology - 1 Apr 2008
Sung Joseph J Y, Tsui Stephen K W, Tse Chi-Hang, Ng Eddie Y T, Leung Kwong-Sak, Lee Kin-Hong, Mok Tony S K, Bartholomeusz Angeline, Au Thomas C C, Tsoi Kelvin K F, Locarnini Stephen, Chan Henry L Y
Abstract excerpt
We aimed to identify genomic markers in hepatitis B virus (HBV) that are associated with hepatocellular carcinoma (HCC) development by comparing the complete genomic sequences of HBVs among patients with HCC and those without. One hundred patients with HBV-related HCC and 100 age-matched HBV-infected non-HCC patients (controls) were studied. HBV DNA from serum was directly sequenced to study the whole viral...
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