Article

Decoding the interconnected splicing patterns of hepatitis B virus and host using large language and deep learning models

2025-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Hepatitis B virus (HBV) infection causes approximately one million deaths annually and remains a major driver of hepatocellular carcinoma. Despite its compact 3.2-kb genome, HBV exhibits extensive alternative splicing. Functionally, HBV splice variants contribute to immune evasion and reduce the likelihood of achieving a functional cure. Here, we show that HBV splicing efficiency—quantified from...

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Literature Corpus work: f47102bc-7115-58a2-afe5-d04ccf50188e
DOI: 10.1101/2025.07.28.667110

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