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Article

Next-generation sequencing revealed divergence in deletions of the preS region in the HBV genome between different HBV-related liver diseases.

The Journal of general virology - 1 Nov 2017

Jia Jian'an, Liang Xiaotao, Chen Shipeng, Wang Hui, Li Huiming, Fang Meng, Bai Xin, Wang Ziyi, Wang Mengmeng, Zhu Shanfeng, Sun Fengzhu, Gao Chunfang

Abstract excerpt

In order to investigate if deletion patterns of the preS region can predict liver disease advancement, the preS region of the hepatitis B virus (HBV) genome in 45 chronic hepatitis B (CHB) and 94 HBV-related hepatocellular carcinoma (HCC) patients was sequenced by next-generation sequencing (NGS) and the percentages of nucleotide deletion in the preS region were analysed. Hierarchical clustering and heatmaps...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

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Source

Identifiers

PMID: 29022863
DOI: 10.1099/jgv.0.000942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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