Article
Molecular pathogenesis and progression of prostate cancer.
Seminars in oncology - 1 Jun 2013
Schrecengost Randy, Knudsen Karen E
Abstract excerpt
Prostate cancer (PCa) is the most commonly diagnosed noncutaneous malignancy and second leading cause of cancer-related deaths in US males. Clinically, locally confined disease is treated surgically and/or with radiation therapy. Invasive disease, however, must be treated with pharmacological inhibitors of androgen receptor (AR) activity, since disease progression is fundamentally reliant on AR activation....
Topics
- Androgen Antagonists
- Androgens
- Animals
- Antineoplastic Agents, Hormonal
- Gene Amplification
- Humans
- Male
- Mutation
- Prostate
- Prostatic Hyperplasia
- Prostatic Neoplasms
- Protein Processing, Post-Translational