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Article

Suppression of the ERK-SRF axis facilitates somatic cell reprogramming.

Experimental & molecular medicine - 23 Feb 2018

Huh Sejong, Song Hwa-Ryung, Jeong Geuk-Rae, Jang Hyejin, Seo Nan-Hee, Lee Ju-Hyun, Yi Ji-Yeun, Lee Byongsun, Choi Hyun Woo, Do Jeong Tae, Kim Jin-Su, Lee Soo-Hong, Jung Jae-Won, Lee Taekyu, Shim Jaekyung, Han Myung-Kwan, Lee Tae-Hee

Abstract excerpt

The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination of drug-inducible vectors encoding transcription factors (Oct4, Sox2, Klf4 and Myc) and a single-cell expansion strategy. This system achieved a high reprogramming efficiency after metabolic and...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 29472703
DOI: 10.1038/emm.2017.279
PMCID: PMC5903827

Genes

SRF
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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