Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons.

Neurobiology of disease - 1 Aug 2009

Levenga Josien, Buijsen Ronald A M, Rifé Maria, Moine Hervé, Nelson David L, Oostra Ben A, Willemsen Rob, de Vrij Femke M S

Abstract excerpt

Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines. We examined the role of functional domains of FMRP in neuronal RNA-granule formation and dendritic transport using different FMRP variants, including the mutant FMRP_I304N and the splice-variant FMRP_Iso12. Both variants are absent from dendritic RNA-granules in Fmr1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microscopy, Confocal
Share to Dendrites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

Share to Hippocampus

Share to In Situ Hybridization

Share to Nucleic Acid Conformation

Share to RNA-Binding Proteins

Share to RNA Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 19464371
DOI: 10.1016/j.nbd.2009.05.004
PMCID: PMC2757577

Genes

FMR1
FXR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons.PMID 19464371Read ↗

FMRP and its Multifunctionality: From Cytosol to Nucleolus and BackSemantic proximity Read ↗

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.Semantic proximity Read ↗

Expression of fragile X mental retardation-1 gene with nuclear export signal mutation changes the expression profiling of mouse cerebella immortal neuronal cell.Semantic proximity Read ↗

Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.Semantic proximity Read ↗

FMRP association with and regulation of Fragile X granules exhibit circuit-dependent requirements for the KH2 RNA binding domainSemantic proximity Read ↗

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequencesSemantic proximity Read ↗

Advances in understanding of fragile X pathogenesis and FMRP function, and in identification of X linked mental retardation genes.Semantic proximity Read ↗

FMRP ribonucleoprotein complexes and RNA homeostasis.Semantic proximity Read ↗

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.Semantic proximity Read ↗

Splice form-dependent regulation of axonal arbor complexity by FMRP.Semantic proximity Read ↗

Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.Semantic proximity Read ↗

Synaptic synthesis of the fragile X protein: Possible involvement in synapse maturation and eliminationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.