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Article

Assessing genetic risk factors for early-onset coronary artery disease in Iranians.

Research and practice in thrombosis and haemostasis - 1 Aug 2026

Mancini Ilaria, Pagliari Maria Teresa, Sadeghian Saeed, Abbasi Seyed Hesameddin, Poorhosseini Hamidreza, Boroumand Mohammad Ali, Lotfi-Tokaldany Masoumeh, Pappalardo Emanuela, Agosti Pasquale, Rosendaal Frits R, Peyvandi Flora

Abstract excerpt

Background: Coronary artery disease (CAD) is a leading cause of death worldwide. Evidence of genetic predisposition is derived mostly from studies of Europeans and East Asians. Objectives: To test selected variants for association with early-onset CAD. Methods: We performed a case-control study of 697 young angiography-defined CAD cases (women aged <55 years, men <45) and 911 age- and sex-matched controls in...

Read the complete abstract on PubMed

Topics

Humans
Male
Coronary Artery Disease
Genetic Predisposition to Disease
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Iran

Age of Onset

Female

Risk Factors

Polymorphism, Single Nucleotide

Middle Aged

Adult

Genetic Risk Score

Middle Eastern People

Source

Open in PubMed Open full text

Identifiers

PMID: 42699092
DOI: 10.1016/j.rpth.2026.106893
PMCID: PMC13542590

Genes

CAD
CDKN2A
CDKN2B
SORT1
CXCL12
F11
F5
LPA
MIA3
TSPAN15
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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