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Article

Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA

21 Feb 2018

Abstract excerpt

nriched lncRNA (STEEL) in angiogenic potential, macrovascular/microvascular identity, and shear stress responsiveness. STEEL is expressed from the terminus of the HOXD locus and is transcribed antisense to HOXD transcription factors. STEEL RNA increases the number and integrity of de novo perfused microvessels in an in vivo model and augments angiogenesis in vitro. The STEEL RNA is polyadenylated, nuclear...

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PMID: 29467285
DOI: 10.1073/pnas.1715182115

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