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Article

Interindividual Regulation of the Breast Cancer Resistance Protein/ABCG2 Transporter in Term Human Placentas.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2018

Bircsak Kristin M, Moscovitz Jamie E, Wen Xia, Archer Faith, Yuen Poi Yu Sofia, Mohammed Moiz, Memon Naureen, Weinberger Barry I, Saba Laura M, Vetrano Anna M, Aleksunes Lauren M

Abstract excerpt

The breast cancer resistance protein (BCRP/ABCG2) is a maternally-facing efflux transporter that regulates the placental disposition of chemicals. Transcription factors and gene variants are important regulatory factors that influence transporter expression. In this study, we sought to identify the genetic and transcriptional mechanisms underlying the interindividual expression of BCRP mRNA and protein across 137...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29386232
DOI: 10.1124/dmd.117.079228
PMCID: PMC5896368

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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