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Article

Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).

PloS one - 1 Jan 2018

Policicchio Benjamin Bruno, Sette Paola, Xu Cuiling, Haret-Richter George, Dunsmore Tammy, Pandrea Ivona, Ribeiro Ruy M, Apetrei Cristian

Abstract excerpt

Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Raltegravir Potassium

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Source

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Identifiers

PMID: 29466356
DOI: 10.1371/journal.pone.0190908
PMCID: PMC5821307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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