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Article

Highly uneven distribution of tenofovir-selected simian immunodeficiency virus in different anatomical sites of rhesus macaques.

Journal of virology - 1 Mar 2004

Magierowska Magdalena, Bernardin Flavien, Garg Seema, Staprans Silvija, Miller Michael D, Van Rompay Koen K A, Delwart Eric L

Abstract excerpt

Antiviral tenofovir monotherapy was used to determine whether drug-selected simian immunodeficiency virus (SIV) variants replaced their wild-type progenitors at the same rate in different tissues of six rhesus macaques. The relative frequencies of drug-resistant and wild-type genotypes were measured longitudinally in blood and in 23 lymphoid and nonlymphoid tissues collected at necropsy. The mutant/wild-type...

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Identifiers

PMID: 14963139
DOI: 10.1128/jvi.78.5.2434-2444.2004
PMCID: PMC369237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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