Article
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.
Nature communications - 21 Jun 2021
Santini Laura, Halbritter Florian, Titz-Teixeira Fabian, Suzuki Toru, Asami Maki, Ma Xiaoyan, Ramesmayer Julia, Lackner Andreas, Warr Nick, Pauler Florian, Hippenmeyer Simon, Laue Ernest, Farlik Matthias, Bock Christoph, Beyer Andreas, Perry Anthony C F, Leeb Martin
Abstract excerpt
In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However, neither parent-of-origin-specific transcription nor imprints have been comprehensively mapped at the blastocyst stage of preimplantation development. Here, we address this...
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