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Dynamics of DNA methylation during development

1 Nov 1993

Abstract excerpt

DNA methylation plays a role in the repression of gene expression in animal cells. In the mouse preimplantation embryo, most genes are unmethylated but a wave of de novo methylation prior to gastrulation generates a bimodal pattern characterized by unmethylated CpG island-containing housekeeping genes and fully modified tissue-specific genes. Demethylation of individual genes then takes place during cell type...

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PMID: 8292001
DOI: 10.1002/bies.950151103

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