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Article

Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition.

PloS one - 1 Jan 2012

Li Ellen, Hamm Christina M, Gulati Ajay S, Sartor R Balfour, Chen Hongyan, Wu Xiao, Zhang Tianyi, Rohlf F James, Zhu Wei, Gu Chi, Robertson Charles E, Pace Norman R, Boedeker Edgar C, Harpaz Noam, Yuan Jeffrey, Weinstock George M, Sodergren Erica, Frank Daniel N

Abstract excerpt

We tested the hypothesis that Crohn's disease (CD)-related genetic polymorphisms involved in host innate immunity are associated with shifts in human ileum-associated microbial composition in a cross-sectional analysis of human ileal samples. Sanger sequencing of the bacterial 16S ribosomal RNA (rRNA) gene and 454 sequencing of 16S rRNA gene hypervariable regions (V1-V3 and V3-V5), were conducted on...

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Identifiers

PMID: 22719818
DOI: 10.1371/journal.pone.0026284
PMCID: PMC3374607

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NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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