Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries.

Atherosclerosis - 1 Dec 2015

Wei Shujie, Zhang Yan, Su Linan, He Kecheng, Wang Qiang, Zhang Yunrong, Yang Dachun, Yang Yongjian, Ma Shuangtao

Abstract excerpt

BACKGROUND: The goal of this study was to establish an apolipoprotein E-deficient (ApoE(-/-)) rat model. METHODS: The ApoE(-/-) rat was created by TALEN-mediated gene targeting in the genetic background of Sprague Dawley rat. Six-to eight-week-old male rats were used in the experiments (n = 10 in each group). RESULTS: After fed with high-cholesterol diet (HCD) for 12 weeks, the ApoE(-/-) rats displayed typical...

Topics

Join the communities discussing this publication.

Cholesterol, Dietary
Diet, High-Fat
Carotid Arteries
Carotid Artery Diseases
Ligation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Atherosclerotic

Rats, Transgenic

Source

Identifiers

PMID: 26545012
DOI: 10.1016/j.atherosclerosis.2015.10.093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries.PMID 26545012Read ↗

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.Semantic proximity Read ↗

The ApoE-Null Golden Hamster: A Novel Model of Atherosclerosis.Semantic proximity Read ↗

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein ESemantic proximity Read ↗

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.Semantic proximity Read ↗

The Role of An Experimental Model of Atherosclerosis: apoE-knockout Mice in Developing New Drugs against AtherogenesisSemantic proximity Read ↗

Do the Apoe-/- and Ldlr-/- Mice Yield the Same Insight on Atherogenesis?Semantic proximity Read ↗

Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouseSemantic proximity Read ↗

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.Semantic proximity Read ↗

Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.Semantic proximity Read ↗

Neointimal formation in two apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility.Semantic proximity Read ↗

Small rodent models of atherosclerosis.Semantic proximity Read ↗

Comprehensive analysis of 1-year-old apolipoprotein E-deficient mice reveals advanced atherosclerosis with vulnerable plaque characteristics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.