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Article

Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish.

Journal of lipid research - 1 Feb 2018

Liu Chao, Kim Young Sook, Kim Jungsu, Pattison Jennifer, Kamaid Andrés, Miller Yury I

Abstract excerpt

Elevated plasma LDL cholesterol is the dominant risk factor for the development of atherosclerosis and cardiovascular disease. Deficiency in the LDL receptor (LDLR) is a major cause of familial hypercholesterolemia in humans, and the LDLR knockout mouse is a major animal model of atherosclerosis. Here we report the generation and characterization of an ldlr mutant zebrafish as a new animal model to study...

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Source

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Identifiers

PMID: 29187523
DOI: 10.1194/jlr.D081521
PMCID: PMC5794413

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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