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Article

Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis.

Atherosclerosis - 1 Nov 2004

Wang Xiaosong, Phelan Shelley A, Petros Christina, Taylor Eric F, Ledinski Gerhard, Jürgens Günther, Forsman-Semb Kristina, Paigen Beverly

Abstract excerpt

Peroxiredoxin 6 (Prdx6; also called antioxidant protein 2, or Aop2) is a candidate gene for Ath1, a locus responsible for the respective susceptibility and resistance of mouse strains C57BL/6J (B6) and C3H/HeJ (C3H) to diet-induced atherosclerosis. To evaluate if Prdx6 underlies Ath1, we compared the diet-induced atherosclerotic lesions in Prdx6 targeted mutant (Prdx6-/-) mice of different genetic backgrounds:...

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Identifiers

PMID: 15488866
DOI: 10.1016/j.atherosclerosis.2004.06.007

Genes

PRDX6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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