Article
Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia.
Circulation research - 20 Jul 2001
Mehrabian M, Wong J, Wang X, Jiang Z, Shi W, Fogelman A M, Lusis A J
Abstract excerpt
The genes contributing to the common forms of atherosclerosis are largely unknown. One approach to dissecting complex traits such as atherosclerosis is to use animal models, such as the mouse, to map and characterize the genetic loci involved. We now report the identification of a locus for aortic lesion formation on mouse chromosome 6 that exhibits a highly significant lod score of 6.7 in a genetic cross between...
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