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Spatial memory deficiency early in 6xTg Alzheimer’s disease mouse model

14 Jan 2021

Abstract excerpt

Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NFTs. Here, we developed and evaluated a novel AD mouse model (6xTg-AD, 6xTg) by crossbreeding...

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PMID: 33446720
DOI: 10.1038/s41598-020-79344-5

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