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Article

Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents

16 Feb 2018

Abstract excerpt

Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection following the cessation of treatment. Drugs called latency-reversing agents (LRAs) are being developed to reactivate latently infected cells and render them...

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PMID: 29451894
DOI: 10.1371/journal.pcbi.1006004

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