RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.

doi:10.1161/ATVBAHA.117.310656

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2018

Cui Xiao-Bing, Luan Jun-Na, Dong Kun, Chen Sisi, Wang Yongyi, Watford Wendy T, Chen Shi-You

Abstract excerpt

OBJECTIVE: The objective of this study is to determine the role and underlying mechanisms of RGC-32 (response gene to complement 32 protein) in atherogenesis. APPROACH AND RESULTS: RGC-32 was mainly expressed in endothelial cells of atherosclerotic lesions in both ApoE-/- (apolipoprotein E deficient) mice and human patients. Rgc-32 deficiency (Rgc32-/-) attenuated the high-fat diet-induced and spontaneously...

Topics

Animals
Atherosclerosis
Cell Adhesion
Cell Cycle Proteins
Coculture Techniques
Disease Models, Animal
Endothelial Cells
Genetic Predisposition to Disease
Human Umbilical Vein Endothelial Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inflammation

Inflammation Mediators

Intercellular Adhesion Molecule-1

Macrophages

Male

Mice, Inbred C57BL

Mice, Knockout, ApoE

Monocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 29449334
DOI: 10.1161/ATVBAHA.117.310656
PMCID: PMC5864544

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RGC-32 (Response Gene to Complement 32) Deficiency Protects Endothelial Cells From Inflammation and Attenuates Atherosclerosis.PMID 29449334Read ↗

Role of response gene to complement 32 in diseasesSemantic proximity Read ↗

A major role for RCAN1 in atherosclerosis progression.Semantic proximity Read ↗

Role of C5b-9 complement complex and response gene to complement-32 (RGC-32) in cancerSemantic proximity Read ↗

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.Semantic proximity Read ↗

Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice.Semantic proximity Read ↗

Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.Semantic proximity Read ↗

Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cellsSemantic proximity Read ↗

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.Semantic proximity Read ↗

Role of C5b-9 and RGC-32 in CancerSemantic proximity Read ↗

Molecular characterization of IL-32 in human endothelial cellsSemantic proximity Read ↗

Knockdown of response gene to complement 32 (RGC32) induces apoptosis and inhibits cell growth, migration, and invasion in human lung cancer cells.Semantic proximity Read ↗

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.