Article
Paternal lineage early onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study.
PLoS genetics - 1 Feb 2018
Eng Kevin H, Szender J Brian, Etter John Lewis, Kaur Jasmine, Poblete Samantha, Huang Ruea-Yea, Zhu Qianqian, Grzesik Katherine A, Battaglia Sebastiano, Cannioto Rikki, Krolewski John J, Zsiros Emese, Frederick Peter J, Lele Shashikant B, Moysich Kirsten B, Odunsi Kunle O
Abstract excerpt
Given prior evidence that an affected woman conveys a higher risk of ovarian cancer to her sister than to her mother, we hypothesized that there exists an X-linked variant evidenced by transmission to a woman from her paternal grandmother via her father. We ascertained 3,499 grandmother/granddaughter pairs from the Familial Ovarian Cancer Registry at the Roswell Park Cancer Institute observing 892 informative...
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