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Article

Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer.

PLoS genetics - 1 Mar 2014

Weinberg Clarice R, Shi Min, DeRoo Lisa A, Taylor Jack A, Sandler Dale P, Umbach David M

Abstract excerpt

Genome-wide association studies typically target inherited autosomal variants, but less studied genetic mechanisms can play a role in complex disease. Sex-linked variants aside, three genetic phenomena can induce differential risk in maternal versus paternal lineages of affected individuals: 1. maternal effects, reflecting the maternal genome's influence on prenatal development; 2. mitochondrial variants, which...

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Identifiers

PMID: 24651610
DOI: 10.1371/journal.pgen.1004174
PMCID: PMC3961172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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