Article
Parent of origin effects on age at colorectal cancer diagnosis.
International journal of cancer - 15 Jul 2010
Lindor Noralane M, Rabe Kari G, Petersen Gloria M, Chen Helen, Bapat Bharati, Hopper John, Young Joanne, Jenkins Mark, Potter John, Newcomb Polly, Templeton Allyson, Lemarchand Loic, Grove John, Burgio Michael R, Haile Robert, Green Jane, Woods Michael O, Seminara Daniela, Limburg Paul J, Thibodeau Stephen N
Abstract excerpt
Genomic imprinting refers to a parent-of-origin specific effect on gene expression. At least 1% of genes in the human genome are modulated in this manner. We sought evidence for genomic imprinting in colorectal cancer by studying the ages at diagnosis in the offspring of 2,061 parent-child pairs...
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