Paternal age effect in autosomal dominant or X-linked de novo variants identified by genome-wide sequencing.

Abstract excerpt

An increased frequency of sporadic autosomal dominant disorders has been observed among children born to older fathers. This paternal age effect is thought to reflect an accumulation of new mutations in the male germ line as DNA replication and cell division continue to occur as men age. Genome-wide sequencing is useful for identifying disease-causing genetic variants in patients with suspected genetic diseases...

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