Article
The impact of CYP3A5 on the metabolism of cyclosporine A and tacrolimus in the evaluation of efficiency and safety of immunosuppressive treatment in patients after kidney transplantation.
Die Pharmazie - 1 Oct 2016
Sienkiewicz B, Hurkacz M, Kuriata-Kordek M, Augustyniak-Bartosik H, Wiela-Hojeńska A, Klinger M
Abstract excerpt
The aim of the study was to determine the impact of CYP3A5 mutation on the serum levels of immunosuppressive drugs (tacrolimus and cyclosporine A), and on the occurrence of acute rejection episodes among patients after kidney transplantation. A limited number of such research in Polish patients was also an important factor encouraging to perform the study. Fifty-two persons were recruited. The tested patients...
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