Article
Clinical impact of the CYP3A5 6986A>G allelic variant on kidney transplantation outcomes.
Pharmacogenomics - 1 Jan 2017
Flahault Adrien, Anglicheau Dany, Loriot Marie-Anne, Thervet Eric, Pallet Nicolas
Abstract excerpt
AIM: Meta-analyses and large cohort studies provide confusing results on the association of the CYP3A5 6986A>G allelic variant and adverse outcomes in kidney transplant recipients under tacrolimus-based immunosuppressive regimen. A residual effect of CYP3A5 recipient genotype is unexpected if kidney transplant recipients have similar exposure of tacrolimus. PATIENTS & METHODS: We have undertaken a...
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