Article
Pharmacogenetics of immunosuppressant polymorphism of CYP3A5 in renal transplant recipients.
Transplantation proceedings - 1 Jan 2000
Larriba J, Imperiali N, Groppa R, Giordani C, Algranatti S, Redal M A
Abstract excerpt
The tacrolimus is metabolized primarily by CYP3A5, a member of the single nucleotide polymorphism family. It shows cytochrome P450 (SNP) in intron 3, which consists of a change of base, G for A, producing a stop codon. The result is a nonfunctional protein (allele *3). Allele *1 is the wild type. The patients that show the allelic variant *3 in homozygosis (G/G) are slow metabolizers of the immunosuppressant,...
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