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Article

Factors affecting the long-term response to tacrolimus in renal transplant patients: pharmacokinetic and pharmacogenetic approach.

International journal of medical sciences - 11 May 2010

Katsakiori Paraskevi F, Papapetrou Eirini P, Sakellaropoulos George C, Goumenos Dimitrios S, Nikiforidis George C, Flordellis Christodoulos S

Abstract excerpt

BACKGROUND: The aim of our study was to determine the impact of CYP3A5*1 and CYP3A5*3 on the kinetics of tacrolimus in renal transplant recipients. MATERIAL AND METHODS: Forty kidney recipients were selected to participate. Maintenance scheme consisted of tacrolimus, a purine inhibitor and a steroid. CYP3A5 genotyping was performed with PCR and RFLP. Pharmacokinetic model was developed with Linear Regression and...

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Identifiers

PMID: 20479955
DOI: 10.7150/ijms.7.94
PMCID: PMC2869454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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