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A MUC5B polymorphism associated with Idiopathic Pulmonary Fibrosis mediates overexpression through decreased CpG methylation and C/EBPβ transcriptional activation

2019-12-19

Abstract excerpt

Idiopathic pulmonary fibrosis is a progressive and fatal lung disease of unknown aetiology. The strongest genetic risk factor associated with IPF development is a MUC5B promoter polymorphism ( rs35705950 ). However, the mechanism underlying its effects remains unknown. In this study we have focused on the molecular consequences of the polymorphism on the regulation of MUC5B expression. We have identified a combi...

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Literature Corpus work
601d4f12-b058-52af-a9e1-a4c6b3447734
DOI
10.1101/2019.12.18.880674
Open publication

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