[18F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers.

doi:10.1212/WNL.0000000000012448

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Article

[18F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers.

Neurology - 7 Sept 2021

Wolters Emma E, Papma Janne M, Verfaillie Sander C J, Visser Denise, Weltings Emma, Groot Colin, van der Ende Emma L, Giannini Lucia A A, Tuncel Hayel, Timmers Tessa, Boellaard Ronald, Yaqub Maqsood, van Assema Danielle M E, Kuijper Dennis A, Segbers Marcel, Rozemuller Annemieke J M, Barkhof Frederik, Windhorst Albert D, van der Flier Wiesje M, Pijnenburg Yolande A L, Scheltens Philip, van Berckel Bart N M, van Swieten John C, Ossenkoppele Rik, Seelaar Harro

Abstract excerpt

OBJECTIVE: To assess the [18F]flortaucipir binding distribution across MAPT mutations in presymptomatic and symptomatic carriers. METHODS: We compared regional [18F]flortaucipir binding potential (BPND) derived from a 130-minute dynamic [18F]flortaucipir PET scan in 9 (pre)symptomatic MAPT mutation carriers (4 with P301L [1 symptomatic], 2 with R406W [1 symptomatic], 1 presymptomatic L315R, 1 presymptomatic...

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PMID: 34210823
DOI: 10.1212/WNL.0000000000012448
PMCID: PMC8448551

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