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Article

Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae.

The Journal of biological chemistry - 15 Jun 1993

Odermatt A, Suter H, Krapf R, Solioz M

Abstract excerpt

We cloned an operon, copAB, from Enterococcus hirae encoding two P-type ATPases of 727 and 745 amino acids, respectively. Both enzymes display heavy metal ion binding motifs in their polar N-terminal region. With an antibody against CopB, we showed on Western blots that expression of the operon is induced by either low or high ambient copper concentrations. Disruption of the copA gene renders the cells dependent,...

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PMID: 8048974

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