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Article

Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase.

The Journal of biological chemistry - 6 Dec 2002

Fan Bin, Rosen Barry P

Abstract excerpt

Escherichia coli CopA is a copper ion-translocating P-type ATPase that confers copper resistance. CopA formed a phosphorylated intermediate with [gamma-(32)P]ATP. Phosphorylation was inhibited by vanadate and sensitive to KOH and hydroxylamine, consistent with acylphosphate formation on conserved Asp-523. Phosphorylation required a monovalent cation, either Cu(I) or Ag(I). Divalent cations Cu(II), Zn(II), or...

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PMID: 12351646
DOI: 10.1074/jbc.M208490200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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