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Article

A new structural paradigm in copper resistance in Streptococcus pneumoniae.

Nature chemical biology - 1 Mar 2013

Fu Yue, Tsui Ho-Ching Tiffany, Bruce Kevin E, Sham Lok-To, Higgins Khadine A, Lisher John P, Kazmierczak Krystyna M, Maroney Michael J, Dann Charles E, Winkler Malcolm E, Giedroc David P

Abstract excerpt

Copper resistance has emerged as an important virulence determinant of microbial pathogens. In Streptococcus pneumoniae, copper resistance is mediated by the copper-responsive repressor CopY, CupA and the copper-effluxing P(1B)-type ATPase CopA. We show here that CupA is a previously uncharacterized cell membrane-anchored Cu(I) chaperone and that a Cu(I) binding-competent, membrane-localized CupA is obligatory...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23354287
DOI: 10.1038/nchembio.1168
PMCID: PMC3578076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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