Article

A First-In-Class Broad Spectrum Inhibitor of Copper Exporting P <sub>1B</sub> -type ATPases

2026-01-24

Abstract excerpt

Copper (Cu) transporting ATPases represent a highly conserved subclass of P-type ATPases with critical roles in Cu export and metalloenzyme synthesis. Despite their important biological roles and association with a wide range of human diseases, no high-affinity small-molecule inhibitors have been described. Here, we identify MKV3 as a first-in-class inhibitor of Cu-transporting P-type ATPases that targets a conser...

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Literature Corpus work: 81a336b2-7003-53aa-8e9c-6f0bf9653309
DOI: 10.64898/2026.01.22.700703

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