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Article

Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.

Genetics - 1 Apr 2018

Gotenstein Jennifer R, Koo Cassidy C, Ho Tiffany W, Chisholm Andrew D

Abstract excerpt

Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the Caenorhabditis elegans peroxidasin PXN-2 results in fully penetrant embryonic or larval lethality. Using genetic suppressor screening, we find that the...

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Identifiers

PMID: 29440357
DOI: 10.1534/genetics.118.300731
PMCID: PMC5887144

Genes

PXN

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Source receipt: pubmed, retrieved 7 Sept 2026.

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