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Article

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.

PLoS genetics - 1 Feb 2016

Morrissey Meghan A, Jayadev Ranjay, Miley Ginger R, Blebea Catherine A, Chi Qiuyi, Ihara Shinji, Sherwood David R

Abstract excerpt

Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers. SPARC regulates numerous cellular processes including integrin-mediated cell adhesion, cell signaling pathways, and extracellular matrix assembly; however, the mechanism by which SPARC promotes cell invasion in vivo remains unclear. A main obstacle in...

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Source

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Identifiers

PMID: 26926673
DOI: 10.1371/journal.pgen.1005905
PMCID: PMC4771172

Genes

SPARC

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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