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Article

Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans.

Current biology : CB - 19 Nov 1998

Fitzgerald M C, Schwarzbauer J E

Abstract excerpt

The basement membrane is a specialized extracellular matrix located at epithelial-mesenchymal boundaries that supports cell adhesion, migration, and proliferation; it is highly conserved between invertebrates and vertebrates [1,2]. One of its component proteins, SPARC (osteonectin/BM-40), binds c...

Topics

Animals
Animals, Genetically Modified
Basement Membrane
Caenorhabditis elegans
Extracellular Matrix
Green Fluorescent Proteins
Luminescent Proteins
Mutation
Osteonectin
Recombinant Fusion Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9822581
DOI: 10.1016/s0960-9822(07)00540-4

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9822581-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans.PMID 9822581Read ↗

The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.Semantic proximity Read ↗

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.Semantic proximity Read ↗

Structures and functions of collagens in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.Semantic proximity Read ↗

Forward genetics identifies cuticle and regulatory genes underlying cellular boundary integrity in C. elegans.Semantic proximity Read ↗

Evolutionary conservation and association of SPARC with the basal lamina in Drosophila.Semantic proximity Read ↗

The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH.Semantic proximity Read ↗

Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegansSemantic proximity Read ↗

Caenorhabditis elegans dpy-14: an essential collagen gene with unique expression profile and physiological roles in early development.Semantic proximity Read ↗

Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.Semantic proximity Read ↗

Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva.Semantic proximity Read ↗

PBRM-1/PBAF-regulated genes in a multipotent progenitorSemantic proximity Read ↗

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