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Article

Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans.

Current biology : CB - 19 Nov 1998

Fitzgerald M C, Schwarzbauer J E

Abstract excerpt

The basement membrane is a specialized extracellular matrix located at epithelial-mesenchymal boundaries that supports cell adhesion, migration, and proliferation; it is highly conserved between invertebrates and vertebrates [1,2]. One of its component proteins, SPARC (osteonectin/BM-40), binds calcium and collagens, and can modulate cell-matrix interactions, so altering cell shape, growth, and differentiation...

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Source

Identifiers

PMID: 9822581
DOI: 10.1016/s0960-9822(07)00540-4

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Importance of the basement membrane protein SPARC for viability and fertility in Caenorhabditis elegans.PMID 9822581Read ↗

The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.Semantic proximity Read ↗

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.Semantic proximity Read ↗

Structures and functions of collagens in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.Semantic proximity Read ↗

Forward genetics identifies cuticle and regulatory genes underlying cellular boundary integrity in C. elegans.Semantic proximity Read ↗

Evolutionary conservation and association of SPARC with the basal lamina in Drosophila.Semantic proximity Read ↗

The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH.Semantic proximity Read ↗

Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegansSemantic proximity Read ↗

Caenorhabditis elegans dpy-14: an essential collagen gene with unique expression profile and physiological roles in early development.Semantic proximity Read ↗

Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.Semantic proximity Read ↗

Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva.Semantic proximity Read ↗

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