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Article

Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment.

Gut - 1 Mar 2018

Rigter Lisanne S, Snaebjornsson Petur, Rosenberg Efraim H, Atmodimedjo Peggy N, Aleman Berthe M, Ten Hoeve Jelle, Geurts-Giele Willemina R, van Ravesteyn Thomas W, Hoeksel Johan, Meijer Gerrit A, Te Riele Hein, van Leeuwen Flora E, Dinjens Winand N, van Leerdam Monique E

Abstract excerpt

OBJECTIVE: Hodgkin's lymphoma survivors who were treated with infradiaphragmatic radiotherapy or procarbazine-containing chemotherapy have a fivefold increased risk of developing colorectal cancer (CRC). This study aims to provide insight into the development of therapy-related CRC (t-CRC) by evaluating histopathological and molecular characteristics. DESIGN: 54 t-CRCs diagnosed in a Hodgkin's lymphoma survivor...

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Topics

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Share to DNA Mismatch Repair
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hodgkin Disease

Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

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Source

Identifiers

PMID: 29439113
DOI: 10.1136/gutjnl-2016-312608

Genes

MLH1
BRAF
KRAS
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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