Article
Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors With 2 or More Somatic Mutations in Mismatch Repair Genes.
Gastroenterology - 1 Sept 2016
Cohen Stacey A, Turner Emily H, Beightol Mallory B, Jacobson Angela, Gooley Ted A, Salipante Stephen J, Haraldsdottir Sigurdis, Smith Christina, Scroggins Sheena, Tait Jonathan F, Grady William M, Lin Edward H, Cohn David E, Goodfellow Paul J, Arnold Mark W, de la Chapelle Albert, Pearlman Rachel, Hampel Heather, Pritchard Colin C
Abstract excerpt
BACKGROUND & AIMS: Some colorectal and endometrial tumors with microsatellite instability not attributable to MLH1 hypermethylation or germline mutations contain 2 or more somatic mutations in genes encoding mismatch repair (MMR) proteins. We sought to define the molecular phenotype of this newly recognized tumor subtype. METHODS: From 2 prospective studies of the efficacy of screening for Lynch syndrome, we...
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