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Article

Risk of secondary malignancy (including breast) in patients with mismatch-repair protein deficiency.

The American journal of surgical pathology - 1 Nov 2014

Clay Michael R, Allison Kimberly H, Folkins Ann K, Longacre Teri A

Abstract excerpt

Lynch syndrome (LS) is an autosomal dominant inherited disease that is associated with an increased risk for colorectal and endometrial cancer due to germline mutations in mismatch-repair (MMR) genes. Whereas primary tumors in this syndrome are widely recognized, the relative risk(s) of secondary malignancies, particularly breast cancer, in LS patients are still poorly characterized. To provide an improved...

Read the complete abstract on PubMed

Topics

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Share to Adenosine Triphosphatases
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

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Share to Mismatch Repair Endonuclease PMS2

Share to MutL Protein Homolog 1

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Share to Neoplasms, Second Primary

Source

Identifiers

PMID: 24921635
DOI: 10.1097/PAS.0000000000000259

Genes

MLH1
PMS2
MSH2
MSH6
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Risk of secondary malignancy (including breast) in patients with mismatch-repair protein deficiency.PMID 24921635Read ↗

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Clinicopathologic Comparison of Lynch Syndrome-associated and "Lynch-like" Endometrial Carcinomas Identified on Universal Screening Using Mismatch Repair Protein Immunohistochemistry.Semantic proximity Read ↗

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