Article
Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivors.
British journal of cancer - 1 Nov 2022
Ykema Berbel L M, Breekveldt Emilie C H, Carvalho Beatriz, van Wezel Tom, Meijer Gerrit A, Kerst Martijn, Schaapveld Michael, van Leeuwen Flora E, Snaebjornsson Petur, van Leerdam Monique E
Abstract excerpt
BACKGROUND: Non-seminoma testicular cancer survivors (TCS) have an increased risk of developing colorectal cancer (CRC) when they have been treated with platinum-based chemotherapy. Previously we demonstrated that among Hodgkin lymphoma survivors (HLS) there is enrichment of rare mismatch repair (MMR) deficient (MMRd) CRCs with somatic hits in MMR genes. We speculate that this phenomenon could also occur among...
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