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Article

Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity.

The Journal of experimental medicine - 5 Mar 2018

Perry Curtis J, Muñoz-Rojas Andrés R, Meeth Katrina M, Kellman Laura N, Amezquita Robert A, Thakral Durga, Du Victor Y, Wang Jake Xiao, Damsky William, Kuhlmann Alexandra L, Sher Joel W, Bosenberg Marcus, Miller-Jensen Kathryn, Kaech Susan M

Abstract excerpt

Eliciting effective antitumor immune responses in patients who fail checkpoint inhibitor therapy is a critical challenge in cancer immunotherapy, and in such patients, tumor-associated myeloid cells and macrophages (TAMs) are promising therapeutic targets. We demonstrate in an autochthonous, poorly immunogenic mouse model of melanoma that combination therapy with an agonistic anti-CD40 mAb and CSF-1R inhibitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

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Source

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Identifiers

PMID: 29436395
DOI: 10.1084/jem.20171435
PMCID: PMC5839759

Genes

TNF
CCL17
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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